What is SPRAVATO®?

SPRAVATO® is a prescription nasal spray that contains esketamine, a medication derived from ketamine. Unlike traditional antidepressants that can take weeks to show effectiveness, SPRAVATO® may provide relief from depressive symptoms within hours or days of treatment.

Is SPRAVATO® Right for You?

Patients may be candidates for SPRAVATO® if they:

• - Have been diagnosed with treatment-resistant depression
• - Have tried two or more antidepressants without adequate improvement
• - Are currently taking an oral antidepressant
• - Are looking for a new approach to depression treatment

The Treatment Process at Empower Therapeutics

Initial Treatment Phase

• - Twice weekly visits for the first 4 weeks
• - Each session lasts approximately 2 hours
• - Patients self-administer the nasal spray under medical supervision
• - Vital signs will be monitored throughout the session

Maintenance Phase

• - Weekly sessions for weeks 5-8
• - May be reduced to every 1-2 weeks thereafter
• - Ongoing monitoring and assessment of progress
• - Continuation of oral antidepressant medication

What to Expect During Treatment

1. Pre-Treatment

• - Medical evaluation and screening
• - Discussion of medical history
• - Review of current medications
• - Blood pressure check

2. During Treatment

• - Comfortable, relaxing treatment rooms
• - Self-administration of nasal spray under supervision
• - Regular monitoring of blood pressure and well-being
• - Rest and recovery period

3. Post-Treatment

• - Monitoring for at least 2 hours
• - Must arrange transportation home
• - No driving until the next day

Safety Information

SPRAVATO® is administered in Empower Therapeutics' certified treatment center under medical supervision to ensure patient safety. Common side effects may include:

• - Dissociation or feeling disconnected
• - Dizziness
• - Nausea
• - Sedation
• - Increased blood pressure

These effects typically resolve within 2 hours of treatment.

Insurance Coverage

SPRAVATO® is covered by many insurance plans, including Medicare, for eligible patients. Empower Therapeutics' staff will work with patients to verify coverage and discuss payment options.

Why Choose Empower Therapeutics?

• - REMS-certified treatment center
• - Experienced medical professionals
• - Comfortable, private treatment rooms
• - Comprehensive patient support
• - Ongoing care coordination
• - Flexible scheduling options

Getting Started

Taking the first step toward treatment is important. The team at Empower Therapeutics understands that deciding to try a new treatment can feel overwhelming, and they're here to support patients through the process.

Schedule a Consultation

Contact Empower Therapeutics to schedule an initial consultation where they will:

• - Review your medical history
• - Discuss your treatment goals
• - Determine if SPRAVATO® is right for you
• - Answer any questions you may have
• - Create a personalized treatment plan

*SPRAVATO® is a registered trademark of Janssen Pharmaceuticals, Inc.

*Individual results may vary. Please consult with Empower Therapeutics' healthcare team to determine if SPRAVATO® is appropriate for your situation.